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Lefamulin BC3781, CAS 1061337-51-6, an investigational pleuromutilin, was tested against a collection of 18 macrolide-susceptible and 42 macrolide-resistant Mycoplasma pneumoniae strains in comparison to azithromycin, erythromycin, tetracycline, doxycycline, and moxifloxacin. Lefamulin was highly active against all strains tested, with all MICs ≤ 0.008 μg/ml. The lefamulin MIC90 (0.002 μg/ml) for macrolide-resistant strains was the lowest among all drugs tested. Minimum bactericidal concentrations were within 2 dilutions of the MIC values, indicating a bactericidal effect.
The designation has been granted for lefamulin to treat community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI).
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